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We report a case of an acute ST-segment elevation myocardial infarction in a patient with traditional cardiac danger components utilizing supraphysiologic doses of supplemental, intramuscular testosterone. In addition, this patient additionally had polycythemia, probably secondary to high-dose testosterone. The patient underwent successful percutaneous intervention of the best coronary artery. Physicians and sufferers should be conscious of the medical penalties of anabolic steroid abuse. Development of an atheromatous plaque perpetuates endothelial dysfunction and promotes platelet aggregation and intracoronary thrombus formation (Ajayi et al 1995; Nieminen et al 1996). Moreover, a component of endothelial dysfunction has been proposed, which may contribute to irregular vessel reactivity.
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- Manifestation of severe coronary coronary heart disease after anabolic drug abuse.
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Anabolic Steroids, Acute Myocardial Infarction And Polycythemia: A Case Report And Review Of The Literature
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Patients also could also be taking concomitant stimulants, corresponding to ephedra, which can confound knowledge and the potential for opposed events. It is likely that the frequency of cardiac occasions is underreported within the medical literature. Moreover, testosterone has been used in the remedy of lowered muscle mass and bone density in addition to anemia. The position testosterone may play within the development of heart problems has more and more turn into the topic of current curiosity . Supraphysiologic doses of anabolic-androgenic steroids , which embrace greater than 30 pure and synthetic derivatives of testosterone, may trigger a wide spectrum of scientific sequalae. Supplemental or physiologic doses of testosterone have noticed expanded use in medical apply lately. Other widespread potential antagonistic results embrace infertility, hepatotoxicity, psychological abnormalities, and gynecomastia .
However, testosterone in physiologic doses could even be beneficial in sufferers with angina , have greater ischemic thresholds and improved high quality of life . Short-term intracoronary administration of testosterone induces coronary artery dilation and increases coronary blood circulate in men with established coronary artery illness . Therefore, an interaction of endogenous components of the patient’s danger profile as properly as the testosterone dosing could additionally be problems with whether adverse events occur. Erythrocytosis has been reported as a potential effect of testosterone, which may be useful in patients with anemia.
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